Breath test diagnosis of Helicobacter pylori in peptic ulcer disease: a noninvasive primary care option.
نویسندگان
چکیده
BACKGROUND Helicobacter pylori is implicated as the causative agent for most duodenal and gastric ulcers. Invasive (endoscopy and biopsy) and noninvasive (serology, breath test) methods are currently available for definitive diagnosis of infectious peptic ulcer disease. METHODS Twenty-six patients with chronic gastritis symptoms underwent upper endoscopy, biopsy, rapid urease test, and [14C]urea breath test for the detection of H pylori. RESULTS Twenty of 26 patients (77 percent) had biopsy-proved H pylori infection. All 20 (100 percent) with definite H pylori proved by invasive diagnosis had strongly positive results on urea breath test. Six patients with absence of H pylori on biopsy had negative urea breath test results. The urea breath test displayed 100 percent sensitivity, specificity, and predictive value compared with endoscopy and biopsy. CONCLUSIONS [14C]Urea breath testing is comparable to endoscopy and biopsy in the diagnosis of H pylori infection and could become useful in primary care settings for noninvasive evaluation of peptic ulcer disease.
منابع مشابه
HELICOBACTER PYLORI Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report
Background: Guidelines on the management of Helicobacter pylori, which cover indications for management and treatment strategies, were produced in 2000. Aims: To update the guidelines at the European Helicobacter Study Group (EHSG) Third Maastricht Consensus Conference, with emphasis on the potential of H pylori eradication for the prevention of gastric cancer. Results: Eradication of H pylori ...
متن کاملGastroduodenal peptic ulcer and Helicobacter pylori infection in children and adolescents.
OBJECTIVES To show important aspects of gastroduodenal peptic ulcer and of Helicobacter pylori infection in children and adolescents. SOURCES Technical textbooks and MEDLINE and LILACS databases including publications between 1966 and 2006. SUMMARY OF THE FINDINGS The etiology of peptic ulcer in children and adolescents may be primary, associated with H. pylori infection, or secondary, in w...
متن کاملHelicobacter pylori infection: A recent approach to diagnosis and management
Helicobacter pylori infection is the most common infection worldwide and is associated with simple dyspepsia, heartburn and peptic ulcer diseases, most commonly leading to upper gastrointestinal bleeding and, ultimately, to the severe complication of gastric malignancy. Ninety percent of duodenal ulcers and 70% of gastric ulcers are associated with helicobacter pylori infections. Noninvasive me...
متن کاملCurrent concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report.
BACKGROUND Guidelines on the management of Helicobacter pylori, which cover indications for management and treatment strategies, were produced in 2000. AIMS To update the guidelines at the European Helicobacter Study Group (EHSG) Third Maastricht Consensus Conference, with emphasis on the potential of H pylori eradication for the prevention of gastric cancer. RESULTS Eradication of H pylori...
متن کاملThe Helicobacter pylori breath test: a surrogate marker for peptic ulcer disease in dyspeptic patients.
BACKGROUND There is interest in noninvasive H pylori testing as a means of predicting diagnosis and determining management in dyspeptic patients. AIMS To assess the value of the 14C urea breath test as a predictor of peptic ulcer disease in patients presenting with dyspepsia. PATIENTS AND METHODS 327 consecutive patients referred for investigation of dyspepsia had a 14C urea breath test per...
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ورودعنوان ژورنال:
- The Journal of the American Board of Family Practice
دوره 10 6 شماره
صفحات -
تاریخ انتشار 1997